Position: Lecturer

Office: Schuster Building Room 3.12

Phone: +44 (0)161 306 3933

Fax: +44 (0) 161 200 3941

Email: jichen.li@manchester.ac.uk

 

Background

     His early work has been mainly concerned with water (from low temperature ice to the supercritical state of water) [1-4], clathrate hydrates [5], water in porous materials [6] and carbon nanotubes [7]. He carried out experimental work using elastic, inelastic, quasi-elastic and neutron Compton scattering facilities in UK and abroad. His work also spanned theoretical modeling of materials using lattice dynamics, molecular dynamics and ab initio quantum mechanical methods [8,9]. These projects involved wide collaborations with scientists from a range of disciplines in a number of fronts to attack problems related to hydrogen bonding in water and water in porous media.

    From 2004, as a member of the newly established biophysics at the University of Manchester, he has strong interest in the structure of water association with biological macromolecules. This interest arises since cells in living organisms contain chemical environments that are composed of very high concentrations of macromolecules such as RNA, DNA and protein as well as complex aggregates of bio-molecules such as membranes, extracellular matrix and cytoskeleton. The structure and function of the biomolecules are determined to a significant extent by the amount of adsorbed water. Apart from the water molecules adsorbed on the hydrophilic groups there are also clusters of water immobilized in the cavities formed due to the secondary structure of the biomolecules.

The interaction between proteins and water, both in terms of structure and function, has only started to be studied intensively by neutron scattering. Our recent studies of water in DNA, proteins, biopolymers and living cells [10,11] shed new light towards our understanding of the structure and dynamics of water in the biological environments. For instance, we found that the water around DNA has been perturbed considerably, the structure of water around DNA is much like high density amorphous ice and the water around a proteolipid membrane is very much like ice VII (with many 5/4 fold-rings). However, the complexity of proteins (consisting of hundreds of amino acids) has so far proven too difficult for us to make a more precise understanding of the relationship between the local structure of water and its interaction with biomolecule. In order to make further progress in this field, we have recently concentrated our effort in the study of water around amino acids - the basic building block of proteins. These molecules exhibit the following properties, small, well characterized and having a known interaction sites with water. These systems provide an excellent opportunity for us to study their hydration states [12].  

 In the past few years, he has given many invited lectures and seminars on the subjects related to water in biological systems and neutron scattering techniques. He is co-author of ~100 publications. He was also a member of committees related to the neutron facilities in UK and Abroad.

References

1. J.C. Li, J.D. Londono, D.K. Ross, J.L. Finney, J. Tomkinson, and W.F. Sherman, J. Chem. Phys. 94 (1991) 6770-6775.

2. A.I. Kolesnikov, J-C. Li, D.K. Ross, O.I. Barkalov, V.V. Sinitsyn, E.G. Ponyatovsky, J. Phys. Lett. A 168 (1992) 308-312.

3.J.C. Li and D.K. Ross, Nature 365 (1993) 327-329 & .J.C. Li, J. Chem. Phys. 105 (1996) 6733-7655.

4. C.H. Uffindell, A.I. Kolesnikov, J-C. Li and J. Mayer, Phys. Rev. B 62 (2000) 5492-5495.

5. J-C. Li and P. Jenniskens, Planetary and space Science 45 (1997) 469-473.

6. J-C. Li, D.K. Ross, L.D. Howe, J.P.A. Fairclough, K.L. Stefanopoulos, R.K. Heenan and K. Ibel, Phys. Rev. B 49 (1994) 5911-5917.

7. G. Reiter, C. Burnham, D.Homouz, P.M. Patzman, J. Mayers, T. Abdul-Redah, A.P. Moravsky, J.C.Li, C-K Loong and A. Kolesnikov, Phys. Rev. Letter 97 (2006) 247801-247804.

8. R. Aswani and J.C. Li, Mol. Liquid 134 (2007) 120-128.

9 X. Gong, J. Li, H. Lu, R Wan, J.C. Li, J. Hu and H. Fang, Nature Nanotechnology (2007) in press.

10. S.V. Ruffle, I. Michalarias, J.C. Li and R.C. Ford, J. Amer. Chem. Soc. 124 (2002) 565-569.

11. R. C. Ford, S. V. Ruffle, I. Michalarias, I. Beta, A. Miller, and J.C. Li, J. Amer. Chem. Soc. 126 (2004) 4682-4688.

12. Y. Zhang, P. Zhang, R. C. Ford, S. Han and J.C. Li, J. Phys. Chem. B 109 (2005) 17784-17786.

 

Research Interests

Neutron Scattering Study of Structure and Dynamics of Water around DNA and Proteins

The interaction of water with proteins with respect to their structure and function is a recently emerging field. We have recently studied water around DNA, proteins and biopolymers using various neutron sources around the world. These studies have shed new light towards the understanding of the structure and dynamics of water in the biological environments. In order to make further progress in this field, we have recently concentrated our effort on the basic building block of proteins - amino acids using inelastic and quasi-elastic neutron scattering techniques and computational methods (molecular dynamics and ab initio quantum mechanics).

Inelastic neutron scattering of hydrogen bonding in ices is of considerable relevance to a range of disciplines where water is considered to be important. It not only provides the foundation for us to understand a range of thermodynamical properties of ices and associated anomalies (e.g. providing the basic experimental information for theoretical modelling, e.g. ab initio quantum chemistry calculations, molecular and lattice dynamical calculations for ice and water), but also equally important for us to understand the role (or interaction) of water around biological systems.

However, the complex structures of DNA/proteins and the conformational arrangements of water molecules around them make it very hard to gain a clear picture of the spatial arrangements, as often only averaged (time and molecule) positions are given. In addition, neutron fluxes are typically weak compared to X-ray sources and this necessitates both long collection times and extremely large crystals. However, using vibrational spectroscopy (including neutron, IR and Raman), we can determine the local structures of water in biological environments by comparing the spectra of known structures, such as exotic phases of ice with those in biological systems. We can thus deduce the interactions between water molecules and DNA/proteins.

The different water structures in protein will result in changes in the vibrational frequencies, such as Amide I and II bands, as observed in the experimental spectra. These changes arise from the local water structure which will inevitably alter the structure and functionality of the biomolecules. Experiments of this type will improve understanding of many phenomena related to protein folding which relies heavily on the H-bonding with surrounding water molecules.

PUBLICATION LIST:

1987

1. Interatomic Pair Potentials for Metallic Alloy Glass

J-C. Li and N. Cowlam, Phys. Chem. Liq. 17 (1987) 29-44.

1988

2. Chemical Short Range Order in Molten MnCu and MnSm Alloys of the Null-matrix Composition

J-C. Li, N. Cowlam and F. He, Phys. Chem. Liq. 18 (1988) 31-41.

1989

3. Atomic Structure of Molten Lithium Halides

J-C. Li, J.M. Titman, G.E. Carr, N. Cowlam and J.-B. Suck, J. Physica B 156&157 (1989) 168-170.

4. Structure of Liquid Ni64B36 Metallic Alloy

J-C. Li, N. Cowlam and S.C. Nunn, J. Physica B 156&157 (1989) 171-173.

5. Interatomic Pair Potentials for Metallic Alloy Glass Ni81B19 and Ni63.7Zr36.3

J-C. Li, N. Cowlam and F. He, J. Non-crystalline Solids 112 (1989) 101-105.

6. Small-Angle Neutron Scattering Study of Adsorbed Water in Porous Vycor Glass: Supercooling Phase Transition and Interfacial Structure

M.J. Benham, J.C. Cook, J-C. Li and D.K. Ross, Phys. Rev. B 39 (1989) 633-637.

7. Small-Angle Neutron Scattering Studies of Adsorbed Water in Porous Vycor Glass

J-C. Li, D.K. Ross, P.L. Hall and R.K. Heenan, J. Physica B 156&157 (1989) 185-189.

8. Small-Angle Neutron Scattering Studies of Water in Porous Solid: Advantage of the Contrast Variation Technique

J-C. Li, M.J. Benham, L.D. Howe and D.K. Ross, Neutron and X-ray Scattering: Complementary Techniques IOP Conference Series 101 (1989) 155-170.

9. Inelastic Incoherent Neutron Scattering Spectra of Single Crystalline and Polycrystalline Ice Ih

J-C. Li, D.K. Ross, P.G. Hall and J. Tomkinson, J. Physica B 156&157 (1989) 376-379.

10. Lattice Dynamic Vibration of Ice in Porous Vycor Glass

J-C. Li, S.M. Bennington, M.B. Benham, D.K. Ross and J. Tomkinson, Neutron and X-ray Scattering: Complementary Techniques, IOP Conference Series 101 (1989) 109-118.

1990

11. Structure and Interatomic Pair Potentials for Fe80B20 Metallic Glass

J-C. Li, N. Cowlam, J. Non-crystalline Solids 117/118 (1990) 148-151.

12. Spin-echo Neutron Scattering Study of Tracer Diffusion of Water in Porous Vycor

J.J Tuck, D.K. Ross and J-C Li, NATO ASI 'H-bond Liquid' (1990) 159-163.

1991

13. Small-Angle Neutron Scattering Studies of Water and Ice in Porous Vycor

J-C. Li, D.K. Ross and M.J. Benham, J. Appl. Crystal. 24 (1991) 792-802.

14. Inelastic Incoherent Neutron Scattering Study of Ice II,V,VI and IX -in region from 2-140 meV

J-C. Li, J.D. Londono, D.K. Ross, J.L. Finney, J. Tomkinson, and W.F. Sherman, J. Chem. Phys. 94 (1991)

6770-6775.

15. Neutron Scattering Studies of Ice Dynamics - Part I

J-C. Li and D.K. Ross, International Conference on 'Physics and Chemistry of Ice' (1991), Sapporo, Japan (eds. N. Maeno and T. Hondoh) P27-34.

16. Neutron Scattering Studies of Ice Dynamics - Part II

J-C. Li and D.K. Ross, International Conference on 'Physics and Chemistry of Ice' (1991), Sapporo, Japan (eds. N. Maeno and T. Hondoh) P35-42.

17. Neutron Scattering Studies of Ice Dynamics - Part III

J-C.Li, D.K.Ross, J.D.Londono and J.L.Finney, International Conference on 'Physics and Chemistry of Ice' (1991), Sapporo, Japan (eds. N.Maeno and T.Hondoh) 43-49.

1992

18. Inelastic Incoherent Neutron Scattering Study of Ice Ih, II, IX, V and VI in Region from 50-500 meV

J-C. Li, J.D. Londono, D.K. Ross, J.L. Finney, S.M. Bennington and A.D. Tayor, J. Phys.: Conddens. Matter 4 (1992) 2109-2116.

19. Inelastic Neutron Scattering Study of Ice VIII

A.I. Kolesnikov, J-C. Li, D.K. Ross, O.I. Barkalov, V.V. Sinitsyn, E.G. Ponyatovsky, J. Phys. Lett. A 168 (1992) 308-312.

1993

20. Structural Simulation of an Amorphisation Reaction

J-C. Li, N. Cowlam and J.E. Evetts, J. Non-crystalline Solids 156/158 (1993) 532-535.

21. Small-Angle Neutron Scattering Studies of the Transition Between Water and Ice in Restricted Geometry

J-C. Li, D.K. Ross and R.K. Heenan, Phys. Rev. B 48 (1993) 6716-6719.

22. Spin-Echo Neutron Scattering Study of Tracer Diffusion of Water in Porous Vycor

J-C. Li, D.K. Ross and C. Lartigue, J. Phys. Condensed Matter 5 (1993) 7529-7536.

23. Evidence of Two Kinds of Hydrogen Bonds in Ices

J-C. Li and D.K. Ross, Nature 365 (1993) 327-329.

1994

24. Elastic Neutron Diffused Scattering Study of the Correlation of Protons in the Structure of Ice Ih

J-C. Li, V.M. Nield, D.K. Ross, R.W. Whitworth, C.C. Willson and D. Keen, Phil. Mag.  69 (1994)  

1173-1181.

25. Dynamic Scaling for Spinodal Decomposition - Small-Angle Study Porous Vycor Glass with Fractal Properties

J-C. Li and D.K. Ross, J. Phys. Condens. Matt. 6 (1994) 351-362.

26.  Small-Angle Neutron Scattering Studies of Percolation Network Formed During Desorption and Adsorption of Water in Porous Vycor Glass

J-C. Li, D.K. Ross, L.D. Howe, J.P.A. Fairclough, K.L. Stefanopoulos, R.K. Heenan and K. Ibel, Phys. Rev. B 49 (1994) 5911-5917.

27. The Observation of Different Strengths of Hydrogen Bonds in Ices

J-C. Li, D.K. Ross, M.H.B. Hayes, W.F. Sherman and M. Adams, NATO ARW on "Hydrogen Bond Networks" (eds. M-C. Bellissent-Funel and J.C. Dore, Kluwer Academic Publishers, 1994) 139-148.

28. The Role of H-bond in the Formation of Ice and Water Structures

J-C. Li and D.K. Ross, NATO ARW on "Hydrogen Bond Networks" (eds. M-C. Bellissent-Funel and J.C. Dore, Kluwer Academic Publishers, 1994) 61-67.

29. Inelastic Incoherent Neutron Scattering Measurements of Ices Dynamics - Observation of the Two Strengths of Hydrogen Bonds in Ices

J-C. Li, D.K. Ross and M.H.B. Hayes, J. Mol. Structure 322 (1994) 131-139.

30. Further Evidence of Two Kinds of Hydrogen Bonds in ice Ih 

J-C. Li, S.M. Bennington and D.K. Ross, Phy. Lett. A 192 (1994) 295-300.

31. Inelastic Neutron Scattering Studies of Defect Modes of H in D2O Ice Ih 

J-C. Li and D.K. Ross, J. Condens Matt. 6 (1994) 10823-10837.

32. Using the PHONON Program for Interpreting Inelastic Neutron Scattering Data

J-C. Li and M. Leslie, Nucl. Instrum. Methods A 354 (1994) 149-163.

33. A Model of Multiscaling Dynamics for Spinodal Decomposition

J-C. Li, Nucl. Instrum. Methods A 354 (1994) 165-168.

1995

34. Disorder in Ice Ih

V.M. Nield, J-C. Li, D.K. Ross and R. W. Whitworth, Physica A T57 (1995) 179.

35. Inelastic Incoherent Neutron Scattering Studies of Ice XI

J-C. Li, V.M. Nield and S. Jackson, Chem. Phys. Lett. 241 (1995) 290-294.

1996

36. The Pressure Dependence of Ice VII and VIII

J-C. Li and M. Adams, EuroPhys. Lett. 34 (1996) 675-680.

37. Inelastic Incoherent Neutron Scattering Studies of hydrogen bonding in Ices

J-C. Li, J. Chem. Phys. 105 (1996) 6733-7655.

1997

38. Inelastic Neutron Scattering Study of High Density Amorphous Water Ice

J-C. Li and P. Jenniskens, Planetary and space Science 45 (1997) 469-473.

39. Total Energy Studies of the Static and Dynamical Properties of Ice Ih and Exotic High Pressure Phases

I.Morrison, J-C.Li, S.Jenkins, S.S.Xantheas and M.C.payne, J. Phys. Chem. 101 (1997) 6146-6150.

40.  Molecular Dynamic Calculations for Ice Ih

C.J. Burnham, J.C. Li and M. Leslie, J. Phys. Chem. 101 (1997) 6192-6195.

41. Some Basic Properties of Ice Dynamics

J-C. Li and M. Leslie, J. Phys Chem. 101 (1997) 6304-6307.

42. Lattice Dynamic Calculations of Ice VIII

S.L. Dong, A. Kolesnikov and J-C. Li, J. Phys. Chem. 101 (1997) 6087-6089.

43. Inelastic Neutron Scattering Studies of Vapour Deposited Amorphous Ice

A. Kolesnikov, J-C. LI, S.L. Dong, I. Balley, W. Hahn. R. Eccelston and S. Parker, Phys. Rev. Lett. 79 (1997) 1869-1872.

44. Neutron Scattering Studies of Ice Prepared by Different Thermobaric Treatments

A Kolesnikov, V.V.Sinitsyn and E.G. Ponyatovsky, I. Natkaniec and L.S. Smirnov and J-C. Li, J. Phys. Chem. 101 (1997) 6082-6086.

45. Effects of Potentials to Vibrational Dynamics of Ice

J-C. Li, J. Phys. Chem. 101 (1997) 6237-6242.

46. Multiphonon Contributions in Inelastic Neutron Scattering Spectra.

A. Kolesnikov and J-C. Li, Physica B 234-236 (1997) 34-36.

1998

47. Molecular Dynamics of Ice Ih Using a Polarizable Potential

C.J. Burnham, J-C. Li and Maurice Leslie, NATO ASI  “Recent Theoretical and Experimental Advances in Hydrogen bondied system” (ed. S.S. Xantheas, 1997) (2000) 403-411.

48. Neutron Spectroscopy of Vapour Deposited Amorphous Ice

A. Kolesnikov and J-C. Li, NATO ASI “Ice Physics in the Natural and Endangered Environment” V56 (eds. J.S. Wettlaufer, J.G. Dash and N. Untersteiner, 1998) 305-308.

49. Lattice Dynamical Calculations for the Proton Ordered Ice II Structure

Y. Wang, S.L. Dong and J-C. Li NATO ASI “Ice Physics in the Natural and Endangered Environment” V 56 (eds. J.S. Wettlaufer, J.G. Dash and N. Untersteiner, 1998) 347-350.

50.Weakened Hydrogen Bond Interactions in the High Pressure Phase of Ice: Ice II

S.L. Dong, Y. Wang, A.I. Kolesnikov and J.C. Li, J. Chem. Phys. 109 (1998) 325-330.

51. Inelastic Neutron Scattering Techniques and Its Applications to Ie Water

Y.Wang and J.C. Li, in “Phyical, Chemical and Biological Properties of Stable Water Ie Clusters” (eds. S.Y. Lo and B. Bonavida, World Scientific Press, 1998) p81-93.

1999

51. Simulation of Inelastic Neutron Scattering Spectra for Water Ice  - A most effective way of testing water potentials.

Jichen Li and John Tomkinson, N2M conference (eds. M.R. Johnson, G.J. Kearley and H.G. Buntter, American Physics Society, New York, 1999), 155-159.

52. Interpretation of Inelastic Neutron Scattering Spectrum by Molecular Dynamics

J-C. Li and J. Tomkinson, invited contribution to a book titled: “Molecular Dybanmics - from Classical to Quntum Methods” (eds P.B. Balbuena and J.M. Seminario, Elsevier Sientific, plc 1999) p471-532.

53. Neutron Spectroscopy of Fullerite Hydrogenated Under High Pressures,

A.I. Kolesnikov, V.E. Antonov, I.O. Bashkin, J.C. Li, A.P. Moravsky, E.G. Ponyatovsky and J. Tomkinson, Physica B 263-264 (1999) 436-438.

54. Neutron Spectroscopy of High-Density Amorphous Ice,

A.I. Kolesnikov, J.C. Li, N.C. Ahmad, C.-K. Loong, J. Nipko, D. Yocum and S.F. Parker, Physica B 263-264 (1999) 560-562.

55. The Vibrational Spectrum And Giant Tunneling Effect Of Hydrogen Dissolved in a-Mn, A.I. Kolesnikov, V.E. Antonov, S.M. Bennington, B. Dorner, V.K. Fedotov, G. Grosse, J-C. Li, S.F. Parker and F.E. Wagner, Physica B 263-264 (1999) 421-423.

56. Simulation of Vibrational Dynamics by Lattice and Molecular Dynamic Simulations

Jichen Li, Physica B 263-264 (1999) 404-407.

57. The Vibrational Dynamics of Amorphous Ice

A. Kolesnikov, J.C. Li, S. Parker, R. Eccleson and C-H. Loong, Phys. Rev. B. 59 (1999) 3569-3578.

58. Neutron Spectroscopic Measurement of Ice VIII

J-C. Li, A.I. Kolesnikov and R.S. Eccleston, Phys. Rev. B. 59 (1999) 9088-9095.

59. Phonon Softening in Ice Ih,

S.M. Bennington, J.C.Li, M. Harris and D.K. Ross, Physica B 263-264 (1999) 396-399.

60. The Parametrization of a Thole-type All-Atom Polarizable Water Model from First Principles and its Application to the Study of Water Clusters (n = 2-21) and the Phonon Spectrum of Ice Ih

C. J. Burnham, J.C. Li, S.S. Xantheas and M. Leslie, J. Chem. Phys. 110 (1999) 4566-4581.

61. Neutron Scattering Study and Lattice Dynamical Simulation of Clathrate H2O+He

S-L. Dong, A. Kolesnikov and J.C.Li, Physica B 263-264 (1999) 429-431.

2000

62. eVS measurements of Water in the Sub- and Supercritical Region

C.H. Uffindell, A.I. Kolesnikov, J-C. Li and J. Mayer, Phys. Rev. B 62 (2000) 5492-5495.

63. Inelastic Neutron Scattering Investigation of Greenland Ices

Y. Wang, J.C. Li, A. Kolesnikov, S. Parker and J. Sigfus, Physica B 276-278 (2000) 282-283.

64. Investigation of Supercritical Water by Neutron Scattering

C.H. Uffindell, A.I. Kolesnikov, J-C. Li and J. Mayer, Physica B 276-278 (2000) 444-445.

65. Lattice Dynamic Calculated Using a Range of Water Potentials for Ice Ih

S.L. Dong and J.C. Li, Physica B 276-278 (2000) 469-470.

2001

66. Potential lattice dynamical simulation of ice

S-L. Dong. Yan. Wang and Jichen Li, Chem. Physics 270 (2001) 309-317.

2002

67. Liquid-like dynamical behaviour of water in silica gel at 5 K

A.I. Kolesnikov, J.C. Li, S.F. Parker, Journal of Molecular Liquids 96-97 (2002) 317-325.

68. Neutron spectroscopic investigation of dynamics of water ice

Jichen Li and A.I. Kolesnikov, Journal of Molecular Liquids 100 (2002) 1-39

69. The first observation of Boson peak from water vapour deposited amorphous ice

J.C. Li and A.I. Kolesnikov, Physica B 316-317C (2002) 493-496.

70. Interaction of water with DNA – a combined inelastic neutron scattering and infrared spectroscopy study  Ilias Michalarias, Ilir Beta, Jichen Li, Stuart Ruffle and Robert Ford, J Molecular liquid 101 (2002) 19-26.

71.  Inelastic incoherent neutron scattering studies of water interacting with biological macromolecules

Stuart V. Ruffle, Ilias Michalarias, Jichen Li and Robert C. Ford, J. Amer. Chem. Soc. 124 (2002) 565-569.

72. Inelastic neutron scattering studies of water in DNA

Ilias Michalarias, Ilir Beta, Robert Ford, Stuart Ruffle, Jichen Li, Applied Physics A 74 (2002) S1242-1244.

73. Inelastic neutron scattering studies of water on bio-polymers.

G.L. Wu, I.A. Beta, J.B. Ma and J.C. Li, Applied Physics A 74 (2002) S1267-1269.

74. The Predictive Capabilities of Water Potentials for the Calculation of Inelastic Neutron Spectroscopy

Jichen Li, a Chapter in “Recent Research Development in Physics” 3 (Transworld research network, Kerala, India 2002) p959-682.

2003

75. Neutron Scattering Studies of the Phase Transitions in High Pressure Ices During Annealing

Y. Wang, A. Kolesnikov, S.L. Dong and J.C. Li, Canadian J. Physics 81 (2003) 401-407.

76. Diffuse Neutron Scattering Studies of Ice Ih Under High Pressures

Y. Wang and J.C. Li, Canadian J. Physics 81 (2003) 409-413.

77. Vibrational dynamics of water in bio-polymers

I. A. Beta, G. L. Wu and J-C. Li, Canadian J. Physics 81 (2003) 367-371.

78. Neutron scattering studies of the dynamics of sub- and super-critical water

I. A. Beta, J. C. Li and M.-C. Bellissent-Funel, Chem. Phys. 292 (2003) 229-234.

79. Defect Hydrogen Vibrations in Various Phases Deuterium Ice

J.C. Li, Y. Wang, S.L. Dong, P. Zhang, and A.I. Kolesnikov, J. Chem. Phys. 119 (2003) 3332-3335.

80. Quasi-elastic neutron scattering study of hydrated DNA

I. A. Beta, I. Michalarias, J.C. Li, R.C. Ford and M.-C. Bellissent-Funel Chem. Phys. 292 (2003) 451-454.

81. Neutron scattering studies of sub and supercritical water

I. Beta, A Kolesnikov and J.C. Li, 4th International Symposium on High Pressure Process Technology and Chemical Engineering, September 22-25, 2002 Venice-Italy (conference precedence 2003).

2004

82. Inelastic incoherent neutron scattering measurements of intact cells and tissues, and detection of interfacial water . Robert C. Ford, Stuart V. Ruffle, Ilias Michalarias, Ilir Beta, Aline Miller, and Jichen Li, JACS 126 (2004) 4682-4688.

83. The proton momentum distribution in water and ice, George Reiter, J.C. Li, J. Mayers, P. Patzman and F. Stillingger, Brazilian J. of Physics 34 (2004) 142-147.

84. Neutron scattering measurements of intact cells show changes after heat shock consistent with an increase in molecular crowding

Robert C. Ford, Stuart V. Ruffle, Ilias Michalarias, Ilir Beta, Anibal Ramirez-Cuesta and Jichen Li, J. Molecular Recognition 17 (2004) 505-511.

85. Structure and dynamics of concentrated aqueous solutions of aluminium and beryllium chloride and of aluminium bromide: Raman, inelastic neutron scattering and X-ray diffraction investigations, A.M. Gaspar, M. A. Marques, M. I Cabaco, M.I. de B Marques. A Kolesnikov and J.C. Li, J. Phys. Condens. Matter 16 (2004) 6343-6364 

86. Using supercritical water manipulates the structures of porous materials and nano-scale particles

J.C. Li, R. Asnwani, X. L. Gao, S. King and A.I. Kolesnikov, NATO ASI (PST 979397) title: Nanoengineered Nanofibrous Materials (Kluwer Academic Book Publishers, Dordrechet, Netherlands, Eds. SI Guceri, Y. Gogotsi and V. Kuznetsov, 2004) p157-162.

87. Muon–Spin-Relaxation Studies of High Pressure Phases of Ice

Y. Wang, S.L. Dong, A.I. Kolesnikov, P. Zhang and J.C. LI, Physica B 350 (2004) E451-454.

2005

88. Inelastic Neutron Scattering Studies of Water In Biomolecules

Ilias Michalarias, Xiuli Gao, Robert C. Ford, Stuart V. Ruffle and Jichen Li, J. Mol. liquid 117 (2005) 107-116.

89. Inelastic Neutron Scattering Studies of the Interaction Between Water and Some Amino Acids,

Ying Zhang, Peng Zhang, Robert C Ford, Shenghao Han and Jichen Li, J. Phys. Chem. B 109 (2005) 17784-17786.

90.  Exerprimental Observations of Water – Framework Interactions ion a Hydrated Microporous Aluminum Phosphate, Huaxin Yang, Richard I Walton, Silke Biedasek, Sesa Zntonijevic and Stephen Wimperis, Anibal J. Ramirez-Cuesta, Jichen Li and Alexander I. Kolesnikov, J. Phys. Chem. 109 (2005) 4464-4469.

91. Vibrational analysis of L-serine using the density functional theory,

Zhang Ying, Yin Wen, Zhang Peng, Xu Chang-ye，Han Sheng-Hao, and Li JiChen. Chinese Physics 14 (2005).

2006

92. The Interaction of Water with Glycine: a combined Inelastic Neutron Scattering and Raman Spectra Studies, Peng Zhang, Ying Zhang,, Shenghao Han, Qiwei Yan, and Jichen Li, Acta Physica Polonica A (2006) 399-404.

93. Vibrational Spectroscopic Studies of the Interaction of Water with Serine

Peng Zhang, Ying Zhang, Shenghao Han, Qiwei Yan, Robert C Ford and Jichen Li*, J. Phys. Chem. B 110 (2006) 5000-5003.

94. Anomalous behaviour of proton zero point motion in water in Carbon nanotubes

George Reiter, C. Burnham, D.Homouz, P.M. Patzman, J. Mayers, T. Abdul-Redah, A.P. Moravsky, J.C.Li, C-K Loong and A. Kolesnikov, Phys. Rev. Letter 97 (2006) 247801-247804.

95. Low-energy neutron vibrational spectra of high pressure phases of ice

A. I. Kolesnikov, J.C. Li, D. Colognesi, Nucl. Instrum. Methods, 14 (2006) 325-331.

2007

96. Inelastic incoherent neutron scattering measurements of intact cells after osmotic shock show changes in interfacial water content.

Robert C. Ford,  Anibal J. Ramirez-Cuesta  and Jichen Li ANTO ARW – Soft Matter Under Exogenic Impacts (editor S J Rzoska and V.A. Mazur 2007) 433-446.

97. New Approach for the Pairwise Potentials for Water-Water Interactions

R. Aswani and J.C. Li, J. Mol. Liquid 134 (2007) 120-128.

98. Neutron spectroscopic and Raman studies of interaction between water and proline

Peng Zhang, Shenghao Han, Ying Zhang, and Jichen Li, J Chem Physics (2006) in press.

99. Molecular pump for water induced by charges

Xiaojing Gong, Jingyuan Li, Hangjun Lu, Rongzheng Wan, Jichen Li, Jun Hu and Haiping Fang, Nature Nanotechnology (2007) in press.

100. Inelastic Neutron Scattering Studies of Water in Superconducting NaxCoO2.yH2O hydrates

H.X. Yang, Y.G. Shi, J.Q. Li, R.I.Walton, A Kolesnikov and Jichen Li, Phys. Rev. B (2007) in press.

 

About Dr Jichen Li

 

Dr Li became a lecturer in Physics at Manchester, after completing his EPSRC advanced fellow from 7/1994-7/1999). He specialises in neutron scattering and related technology. His recent work has been mainly concerned with hydrogen bonding in water (from Ice to the supercritical state), clathrate hydrates, water in C60/C nanotubes and in biomaterials). This area of work is highly interdisciplinary, requiring both experimental work using inelastic, quasi-elastic and neutron Compton scattering and theoretical modeling of hydrogen bonding using lattice dynamics (LD), molecular dynamics (MD) and ab initio quantum mechanical methods.  He has collaborated with scientists from a wide range of disciplines. He is co-author of ~100 publications. He has given many invited lectures and seminars on water structuring and inelastic neutron scattering. He is a member of several committees related to neutron scattering in UK and abroad.

 

Select publications:

1. J.C. Li, J.D. Londono, D.K. Ross, J.L. Finney, J. Tomkinson, and W.F. 4. Sherman, J. Chem. Phys. 94 (1991) 6770-6775.

2. A.I. Kolesnikov, J-C. Li, D.K. Ross, O.I. Barkalov, V.V. Sinitsyn, E.G. Ponyatovsky, J. Phys. Lett. A 168 (1992) 308-312.

3. J.C. Li, V.M. Nield and S. Jackson, Chem. Phys. Lett. 241 (1995) 290-294.

4. J.C. Li and M. Adams, EuroPhys. Lett. 34 (1996) 675-680.

5. J.C. Li and D.K. Ross, Nature, 365 (1993) 327-329.

6. I. Morrison, J.C. Li, S. Jenkins, S.S. Xantheas and M.C. Payne, J.Phys. Chem. 101 (1997) 9146-9150.

7. J.C. Li and M. Leslie, J. Phys. Chem. 101 (1997) 6304-6307.

8. C.J. Burnham,  J.C.Li, S.S. Xantheas and M. Leslie, J. Chem. Phys. 110 (1999) 4566-4581.

9. C.J. Burnham, J.C. Li and M. Leslie, for J. Phys. Chem. 101 (1997) 6192-6195.

10. J.C. Li and P. Jenniskens, Planetary and space Science, 45 (1997) 469-473.

11. J-C. Li and J. Tomkinson, invited contribution to a book titled: “Molecular Dynamics - from Classical to Quantum  Methods” (eds. P.B. Balbuena and J.M. Seminario, Elsevier Scientific, plc 1999) p471-532.15. J. Mayers Phys. Rev. Lett. 71 (1993) 1553.